Antiphospholipid Syndrome 

What is it?

Antiphospholipid antibody syndrome (commonly called antiphospholipid syndrome or APS) is an autoimmune disease present mostly in young women. Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). – See more at:\

APS is an autoimmune disease which can cause frequent clotting in arteries and veins and/or miscarriages. The clotting results from the presence of proteins in the blood called anti-phospholipid autoantibodies (commonly called aPL) formed against the person’s own tissues. These autoantibodies interfere with coagulation, leading to increased clot formation or thrombosis (in which blood flow stops due to a clot). See more at:

Complications of APS

The damage caused by this clotting can vary depending on the site of the clot. For instance, repeated small clots in the heart can cause heart valve thickening or damage, with the risk of releasing clots into blood (called an arterial embolism). The autoantibodies (aPL) also may be associated with heart attacks in young people without any known cardiac risk factors. Blood clots in the arteries in the heart can lead to heart attacks, while blood clots in the arteries in the brain can result in strokes. Blood clots from aPL can occur anywhere in the circulation and can affect any organ in the body.

Clots forming in the veins most frequently occur in the lower legs. Blood clots in the leg veins can break off and travel to the lung, causing a very serious condition called pulmonary embolism. Pulmonary embolism blocks blood flow to the lung and decreases the amount of oxygen in the blood.

In a few cases, repeated thrombotic events may take place in a short time, leading to the progressive damage of several organs. This acute and life-threatening condition is called catastrophic APS. Patients with APS may suffer from other problems including low number of platelets, mottled purplish discoloration of the skin (livedo reticularis), and skin ulcerations.

For pregnant women, aPL can lead to early and late miscarriage and pre-eclampsia (high blood pressure and protein in the urine during pregnancy). Originally it was suggested that aPL were responsible for clots in the placenta’s blood vessels, causing fetal growth retardation. aPL also may directly attack the placental tissues, blocking their growth and development. See more at:

What causes APS?

Why patients develop anti-phospholipid autoantibodies (aPL) is not completely understood. – See more at:

Diagnosing APS

 The diagnosis of antiphospholipid syndrome is made by testing the blood of patients with blood clots and/or recurrent miscarriages for the presence of anti-phospholipid autoantibodies (aPL). Screening is done using two kinds of tests. Tests may vary because of the differences in the aPL from patient to patient.  Each single test cannot detect all of the possible autoantibodies, so their combined use is strongly advised. At least one of these tests must prove positive, and be confirmed on two occasions no less than three months apart. In general, the higher the level of the test and the greater number of positive tests increases the risk of developing symptoms. Having positive blood tests alone in the absence of a clot does not make a diagnosis of antiphospholipid syndrome. There are healthy people who carry these clotting proteins in their blood who never have a clot in their lifetimes. – See more at:

Current Treatment for APS

Most often, anti-phospholipid autoantibodies are detected after a clotting event or recurrent miscarriages. Therefore, the main goal of therapy is prevention of recurrences, because the presence of the antibodies puts the patient at strong risk for future episodes.

Vascular events

Acute thrombotic events are treated with anticoagulants (blood thinners), initially with intravenous heparin and then followed by oral warfarin (Coumadin). In serious situations, some patients also are given compounds that dissolve clots quickly.

In patients with aPL, oral anticoagulation is required to avoid recurrences of venous blood clots, possibly over a period of years. For arterial events, recurrences also are prevented with drugs that inhibit platelets, such as aspirin and clopidogrel (Plavix).

Pregnancy-related events

Subcutaneous injections of heparin and low-dose aspirin are the standard therapy for preventing miscarriages. The therapy is started at the beginning of the pregnancy and continued in the period immediately after the delivery. This therapeutic approach has been shown to be effective in the majority of the cases, with delivery of healthy babies. In non-responsive cases, additional therapies such as intravenous immunoglobulin infusions and administration of corticosteroids (prednisone) may help.

Pregnant women who had previous blood clots may receive the same combination of heparin and low-dose aspirin—but with higher doses of heparin—because of the increased risk of blood clots.  The therapy with heparin and aspirin has been shown to be safe for both the mother and the baby.  When antibodies are detected in patients with no prior thrombotic events or miscarriages, the need for preventive therapy must be evaluated case by case. However, it is generally accepted that treatment is not necessary if no additional risk factors for clotting or an associated systemic autoimmune disease (i.e. Lupus) are present.

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