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Unlocking Autoimmunity Inc. has specifically chosen to directly fund these research institutes and labs for their dedication and the exceptional work that they are doing and have been doing for many years. After much personal research over several years on those currently conducting research to help discover better treatments and/or cures for these debilitating diseases we feel very confident with those chosen below. Our reason in going forth with directly funding labs is to avoid any overhead costs and time for money from organizations to dispense funds to these labs. We hope to get these donations straight to those working daily, diligently and spending countless hours to discover the mystery of these diseases. The hope/vision is to make it easier for them to receive the money so they can continue to move forward and not remain in a waiting period.  Please take the time to read about the work that they are conducting. We are  more than supportive should you choose to donate to another non-profit organization for autoimmune research. If this brings more awareness and you choose to donate elsewhere then everyone still benefits. We know that there are many other research labs working very hard and have the same commitment and dedication that need funding however are difficult to find. Please feel free to email us to discuss donating to your lab/research. Thank you for all that you do!

 

OUR GOAL? ENDLESS AND ONGOING.....

Stanford School of Medicine

Dr. PJ Utz

Studying the Immune System to Improve Patients’ Lives 

We are part of the Department of Medicine, Division of Immunology at Stanford University School of Medicine. We are interested in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, myositis, primary biliary chirosis (PBC), Sjögren’s disease, insulin dependent diabetes (type I diabetes or IDDM), multiple sclerosis (MS) and mixed connective tissue disease (MCTD). The Utz lab is comprised of approximately 12 scientists, including Postdoctoral Fellows, Research Assistants, Undergraduate Students and Graduate Students. The focus of our research centers on serum autoantibodies produced in a variety of autoimmune diseases. In addition to trying to better understand the pathogenic mechanisms involved in autoimmunity, we are interested in developing bench-to-bedside technologies, including diagnostics and therapeutics, for human autoimmune diseases.

Yale School of Medicine

Dr. Martin Kriegel

UFHealth

University of Florida- Gainesville

Dr. Laurence Morel

Dr. Laurence Morel’s Lab

Drugs for Metabolism could Reverse Lupus Read More!

Recent advances in the understanding of how immune cells utilize nutrients provide new opportunities to target cellular metabolism to treat patients with autoimmune diseases such as lupus. Dr. Morel uses experimental models to identify novel approaches to target autoimmune cells in lupus without affecting the normal immune system that provides protection against infections. In particular, she investigates how we can use existing drugs to limit nutrient access to immune cells and improve disease outcomes.

Stanford School of Medicine

Drs. Judith Shizuru & Irv Wiessman 

Researchers devise method for bone marrow transplants without using chemotherapy Read More

Blood stem cell transplantation, widely known as bone marrow transplantation, is a powerful technique that potentially can provide a lifelong cure for a variety of diseases. But the procedure is so toxic that it is currently used to treat only the most critical cases.

Now, researchers at the Stanford University School of Medicine have come up with a way of conducting the therapy that, in mice, dramatically lowers its toxicity. If the method eventually proves safe and effective for humans, it potentially could be used to cure autoimmune diseases like lupus, juvenile diabetes and multiple sclerosis; fix congenital metabolic disorders like “bubble boy” disease; and treat many more kinds of cancer, as well as make organ transplants safer and more successful.

UFHealth

University of Florida- Gainesville

Dr. Todd Brusko

The research program in the Brusko Laboratory focuses on studying the human immune response in individuals that develop autoimmunity in an effort to develop better ways to predict, intervene, and ultimately treat individuals with type 1 diabetes. The laboratory is particularly interested in the fundamental events that control T cell activation and expansion, as these events are defective in individuals that develop type 1 diabetes. Of the various pathways that control immune responses, regulatory T cells (Tregs) have been shown to be central in controlling T cell activation and preventing diabetes development. Prior studies have already shown that antigen-specific Tregs can prevent, and even reverse diabetes in animal models. A major effort within the Brusko laboratory involves the generation of antigen-specific human Tregs to specifically suppress the immune response targeting islet beta-cells, while leaving the immune response to foreign agents intact. Additional studies are focused on identifying the genetic factors that lead to a breakdown in the mechanisms that maintain immune tolerance. These studies have identified several susceptibility genes that lead to defects in both the innate and adaptive immune responses in patients with T1D. The goal of these studies is to develop targeted therapies in an effort to correct specific defects in pathways that lead to disease.

Johns Hopkins Medicine 

Center for Autoimmune Disease Research 

 Recent scientific advances are giving us an unprecedented opportunity to fight autoimmune diseases. While all of the efforts to advance our understanding of autoimmune diseases are rapidly proceeding at Johns Hopkins, we have more leads than we have resources to pursue them. You can help to continue these efforts by making a tax-deductible donation to the Autoimmune Disease Research Center. The Center can elevate the fight against autoimmune diseases to a new level, acting as a catalyst to spark the expertise of faculty in many disciplines, encouraging the addition of new faculty and activities, and leading the way in the pursuit of innovative ideas.

READ MORE HERE

The Lamb Foundation for Dysautonomia Research

The Lamb Foundation for Dysautonomia Research is truly a grassroots collaboration between our family and what we refer to as our “Dream Team” (Drs. Ian Butler & Mohammed Numan-Co Directors of the Dysautonomia Center for Excellence and Ms. Rebecca Martinez, RN, BS, Dysautonomia Research Nurse). We learned that significant research was being conducted at UTHSC on Dysautonomia and our family wanted to be involved, as we have two children (as well as myself-newly diagnosed!) suffering from Dysautonomia.